
These findings suggest that the iADRS is a useful integrated measurement tool for treatment trials of individuals with mild AD dementia.Īlzheimer’s disease clinical trials iADRS outcome measure. Across the Phase 3 solanezumab trials, iADRS was the only tool that consistently differentiated between solanezumab and placebo groups. Li et al., 2019 Salloway et al. Disease Assessment Scale cognitive subscale (ADAS-Cog) is an eleven-task screening tool developed for detecting early cognitive changes due to Alzheimers. A statistically significant difference between placebo and active drug was observed for iADRS score change from baseline at Week 28 (p=0.028) through Week 80 (p=0.015). The ADAS-Cog is commonly used to monitor the progression of cognitive symptoms in dementia due to Alzheimer’s Disease (AD), and it has been used as a primary cognitive outcome measure across many large-scale randomized clinical trials (Connor & Sabbagh, 2008 Honig et al., 2018 D.-D. Secondary analysis showed that earliest detectable ADAS-cog and MMSE decline in AD was at 16 months, while several specific neuropsychological indices were. We assessed the performance of iADRS in the solanezumab EXPEDITION3 study, an 80-week, placebo-controlled study of individuals with mild AD dementia. It demonstrates acceptable psychometric properties, and is effective in capturing both disease progression and separation of placebo and active drug effect. LADAS-Cog a été développé comme une échelle en deux parties: une qui mesurait les fonctions cognitives et une qui mesurait des fonctions non cognitives telles que lhumeur et le comportement. These ratings are based on information gathered during the interview. LADAS-Cog se compose de 11 parties et prend environ 30 minutes à administrer. Following the objective testing, subjective clinical ratings of language ability and the ability to remember subtest instructions are recorded by the tester.

The Integrated Alzheimer's Disease (AD) Rating Scale (iADRS) is a composite tool that combines scores from the AD Assessment Scale-Cognitive subscale (ADAS-Cog) and the AD Cooperative Study - instrumental Activities of Daily Living (ADCS-iADL). The subtests of the ADAS-Cog should be given in the order indicated.
